AF-500TM Automated Fill and Seal System

Moving from concept to commercialization, the CellSeal AF-500 delivers the automation difference in a precision engineered, GMP compatible, fill-finish system.

This product is sold by

  • Automatic sterile filling and sealing of vials (ten 2 mL or 5 mL vials per set)
  • Fills and seals up to 400 CellSeal vials per hour*
  • Transfers source material through needleless Luer fittings on the nozzle and the vials
  • Customizable vial fill volume

Handling your solution with care

  • Source material is protected from heat exposure during sealing state
  • Filling accuracy is >99% for fill volumes from 0.8 mL to 5 mL

Data collection

  • Remote software records and stores process parameters of the system during operation
  • Temperature of your source material may also be recorded

* Rate may vary with fill volume and product-specific flow limitations.

User specifications

  • Use in biosafety cabinet, isolators, or controlled benchtop environment
  • Electricity (108-125/220-245 VAC 50/60 Hz)
  • Compatible with vaporized hydrogen peroxide sterilization

System dimensions

  • 117.5 cm wide x 50.7 cm high x 50 cm deep

Electronic control cabinet dimensions

  • 60 cm wide x 45.1 cm high x 21 cm deep


  • AF-500 in-hood assembly: 95 kgs
  • Electrical cabinet: 30 kgs
CellSeal Cryogenic Vials 10Set
wdt_ID Description Quantity Per Box RPN Order Number
1 2 mL Needleless 10Set 10 packs of 10 vials CSV-047-10SET G47620
3 5 mL Needleless 10Set 10 packs of 10 vials CSV-049-10SET G47622
Connection Kit
wdt_ID Description Quantity Per Package RPN Order Number
1 Transfer kit 1 per package TK-500 G57458

Unless otherwise noted, CellSeal products are intended for laboratory research, bioprocessing, or manufacturing use only. Any use for diagnostic purposes, direct transfusion, or in the production of therapeutic product(s) or vaccine(s) may require advance regulatory review or approval. Determining the need for and seeking regulatory approval is the sole responsibility of the CellSeal product user. Cook Regentec will provide support in the form of testing data or Master File cross reference authorization as available and upon request. If you have any questions, please contact us at info@sextonbio.com.